Atividade antiproliferativa em extratos de Feijoa sellowiana e Psidium cattleyanum
DOI:
https://doi.org/10.31285/AGRO.29.1549Palavras-chave:
araçá, câncer de bexiga, citotóxico, feijoa, goiabeira-serranaResumo
O câncer de bexiga é um problema de saúde humana relevante em todo o mundo. Embora existam várias quimioterapias disponíveis, muitas delas apresentam efeitos colaterais indesejados e são propensas a desenvolver resistência ao tratamento, de modo que eventualmente se tornam ineficazes, causando baixas taxas de sobrevivência. A busca por atividades citotóxicas seletivas (antiproliferativas) em células cancerígenas a partir de extratos de plantas selvagens aumentou significativamente nos últimos anos. Neste trabalho, o efeito antiproliferativo de extratos alcoólicos totais de folhas e flores de feijoa (Feijoa sellowiana) e araçá (Psidium cattleyanum) foi avaliado. A atividade citotóxica foi avaliada com base em ensaios de resazurina e sulforrodamina B em linhagens de células de câncer de bexiga RT4, HT1197 e EJ138. Os resultados obtidos indicaram que um extrato de flor de araçá (ExAF) mostrou uma forte atividade antiproliferativa dependente da concentração. Além disso, ExAF revelou alta seletividade com efeitos citotóxicos muito baixos na linhagem de células HaCaT derivadas de queratinócitos. Dessa forma, o ExAF seria um candidato promissor para estudos mais aprofundados de sua atividade antitumoral. Esses resultados contribuem para a valorização dessas espécies nativas ao expandir seu potencial de uso em novas áreas tecnológicas.
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